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Donald Poirier Selected Research

Oxidoreductases (Dehydrogenase)

1/2022An irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 inhibits estradiol synthesis in human endometriosis lesions and induces regression of the non-human primate endometriosis.
4/2021A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models.
1/2019A- and D-Ring Structural Modifications of an Androsterone Derivative Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3: Chemical Synthesis and Structure-Activity Relationships.
12/2018Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10.
12/2018Chemical synthesis of C3-oxiranyl/oxiranylmethyl-estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 1.
1/2018Pharmacokinetic profile of PBRM in rodents, a first selective covalent inhibitor of 17β-HSD1 for breast cancer and endometriosis treatments.
1/2017Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models.
5/2016Synthesis of a dansyl-labeled inhibitor of 17β-hydroxysteroid dehydrogenase type 3 for optical imaging.
12/2015Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer.
1/2014Discovery of a non-estrogenic irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 from 3-substituted-16β-(m-carbamoylbenzyl)-estradiol derivatives.
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Donald Poirier Research Topics

Disease

32Breast Neoplasms (Breast Cancer)
11/2021 - 02/2002
30Neoplasms (Cancer)
10/2022 - 05/2004
18Prostatic Neoplasms (Prostate Cancer)
10/2021 - 03/2003
7Leukemia
07/2013 - 05/2007
6Endometriosis
01/2022 - 01/2015
3Alzheimer Disease (Alzheimer's Disease)
12/2018 - 07/2009
3Acne Vulgaris
09/2010 - 03/2003
3Endometrial Neoplasms (Endometrial Cancer)
07/2009 - 03/2003
2Pancreatic Neoplasms (Pancreatic Cancer)
02/2020 - 01/2019
2Osteoporosis
09/2010 - 07/2009
2Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
07/2009 - 03/2003
2Hirsutism
07/2009 - 03/2003
1Flaviviridae Infections
01/2020
1Ovarian Neoplasms (Ovarian Cancer)
01/2018
1Carcinogenesis
07/2017
1Hyperplasia
05/2016
1Endocrine Gland Neoplasms (Cancer, Endocrine)
01/2015
1Thrombosis (Thrombus)
05/2013
1Inflammation (Inflammations)
05/2013
1Glioma (Gliomas)
03/2013
1Neoplasm Metastasis (Metastasis)
03/2009
1Choriocarcinoma
03/2009
1Uterine Cervical Neoplasms (Cancer of the Cervix)
03/2009
1Carcinoma (Carcinomatosis)
03/2009
1Ovarian Epithelial Carcinoma
03/2009
1Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
02/2007

Drug/Important Bio-Agent (IBA)

28Estrogens (Estrogen)FDA Link
01/2022 - 11/2002
19EnzymesIBA
11/2021 - 03/2003
17Oxidoreductases (Dehydrogenase)IBA
01/2022 - 03/2009
15AndrogensIBA
10/2021 - 05/2004
13Estradiol (Delestrogen)FDA LinkGeneric
01/2022 - 12/2005
12SteroidsIBA
05/2021 - 05/2004
10Hormones (Hormone)IBA
11/2021 - 12/2005
7RM-581IBA
10/2022 - 01/2017
73 (or 17)-beta-hydroxysteroid dehydrogenaseIBA
04/2010 - 11/2002
6EstroneFDA Link
01/2022 - 02/2008
4Biological ProductsIBA
10/2022 - 03/2003
4androstaneIBA
10/2022 - 05/2007
4LigandsIBA
01/2019 - 12/2008
4SulfatasesIBA
10/2018 - 03/2009
4Pharmaceutical PreparationsIBA
11/2016 - 03/2013
3Dihydrotestosterone (Androstanolone)IBA
11/2021 - 04/2010
3quinolineIBA
05/2021 - 11/2014
3MestranolFDA Link
02/2020 - 01/2017
3Steryl-Sulfatase (Steroid Sulfatase)IBA
10/2018 - 03/2009
3Protein Isoforms (Isoforms)IBA
05/2011 - 03/2009
2Estrogen ReceptorsIBA
01/2019 - 02/2002
2PiperazineIBA
01/2017 - 11/2014
2Gonadal Steroid Hormones (Sex Hormones)IBA
12/2015 - 12/2009
2Proline (L-Proline)FDA Link
11/2014 - 11/2012
2Coordination ComplexesIBA
07/2013 - 12/2008
2Aromatase (CYP19)IBA
12/2009 - 03/2009
2HydroxysteroidsIBA
07/2009 - 03/2003
1Hydroxysteroid DehydrogenasesIBA
11/2021
1Antineoplastic Agents (Antineoplastics)IBA
10/2021
1Docetaxel (Taxotere)FDA Link
10/2021
1Dehydroepiandrosterone (DHEA)IBA
04/2021
1ProdrugsIBA
02/2020
1sulfamic acid (ammonium sulfamate)IBA
02/2020
1Acetates (Acetic Acid Esters)FDA Link
02/2020
1Phosphates (Orthophosphate)IBA
02/2020
1Antiviral Agents (Antivirals)IBA
01/2020
1Androgen Receptors (Androgen Receptor)IBA
01/2020
1estradiol sulfateIBA
01/2019
1Cyclin D1IBA
10/2018
1DNA (Deoxyribonucleic Acid)IBA
10/2018
1SolutionsIBA
01/2018
1RM-532-105IBA
01/2017
1pyrrolidineIBA
01/2017
1Androstenedione (4 Androstene 3,17 dione)IBA
01/2017
1AndrosteroneIBA
01/2017
1Testosterone (Sustanon)FDA Link
01/2017
11,2,3,4-tetrahydroisoquinolineIBA
08/2016
1CopperIBA
05/2016
1Selective Estrogen Receptor Modulators (SERM)IBA
02/2015
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
01/2015
1Methylcellulose (BFL)IBA
01/2015
1EM-1913IBA
08/2013
1NucleotidesIBA
05/2013
1CD39 antigenIBA
05/2013
1GlucocorticoidsIBA
01/2013
1Progesterone Receptors (Progesterone Receptor)IBA
01/2013
1Amino AcidsFDA Link
05/2011
1Epoxy Compounds (Epoxides)IBA
03/2011
1Aromatase InhibitorsIBA
09/2010
1antineoplaston A10 (A 10)IBA
09/2010
1Messenger RNA (mRNA)IBA
03/2009
1estrone sulfataseIBA
03/2009
1Androgen Antagonists (Antiandrogens)IBA
04/2007
1Estrogen Receptor Modulators (Antiestrogen)IBA
04/2005
1Dihydrotachysterol (AT 10)IBA
02/2002
1PolyphenolsIBA
02/2002
1matrigelIBA
02/2002
1CarcinogensIBA
02/2002
1anthraceneIBA
02/2002

Therapy/Procedure

8Therapeutics
01/2022 - 04/2005
1Drug Therapy (Chemotherapy)
10/2021
1Aftercare (After-Treatment)
04/2021
1Subcutaneous Injections
01/2015